Researchers in Finland and Germany have developed an open-source software that will make it significantly easier to process bioimaging data. The software, named BioImageXD, will help in analysing cell and tissue functions. The work to develop the software has been funded by the Academy of Finland (through the FinNano Research Programme), the European Union and Tekes – the Finnish Funding Agency for Technology and Innovation. Version 1.0 of BioImageXD has been accepted for publication in Nature Methods, the top journal in the field.
Among other things, the BioImageXD software is a tool for analysing how molecules move on cell surfaces and how they bond together. With the software, scientists can analyse the composition of cell surfaces, study how cancer cells spread in a three-dimensional environment, or measure how effectively viruses and targeted drugs enter cells. Such calculations have not been possible before.
In recent years, cell and tissue imaging with new, specialised microscopes has considerably advanced research in bioscience and biomedicine. The new methods also allow for studies on living cells. However, the microscopic images are not displayable as such and need to be rendered into three-dimensional models. These 3D renderings carry significant weight as evidence already by themselves, but reliable scientific data also requires numerical values, which can then be used in mathematical calculations. In addition, these calculations must be feasible with extremely large datasets.
So far, the lack of suitable software has clogged up this development. To solve the problem, researchers in Turku, Jyväskylä and Dresden drew up precise specifications for software for processing of imaging data. A key criterion was that the software would be based on the principles of open source, freely available to all researchers.
The work resulted in BioImageXD, a software program that thanks to its versatile and open-source nature has received much positive feedback from hundreds of researchers around the world.